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AMSA An. Mat. Sint. Affini S.p.A. Unipersonale
Registered Office: Viale del Ghisallo 20, 20151 Milano (MI) – Italy
R.E.A. Milano 601857
Cosma S.p.A. Unipersonale
Registered Office: Via Colleoni 15-17, 24040 Ciserano (BG) – Italy
R.E.A. Bergamo 167479
Clarochem Ireland Ltd.
Registered Office: Damastown, Mulhuddart, Dublin 15 – Republic of Ireland
VAT No. IE6517797I




Based nearby the worldwide recognized beauties of Como Lake since 1953, when it was founded by Giuseppe Rebuzzini, AMSA is the first manufacturing company of the CFM group, although it was substantially renovated over the years. AMSA first gained US FDA approval in 1998. The production plant has a 60,000L capacity mostly utilized for small-medium volume APIs, in both generics and fast growing custom synthesis sector.


Viale Giuseppe di Vittorio, 6, 22100 Como (CO)


More than 5000 m2

Reaction volume

52m3 of glass-lined


AMSA, Cosma and Clarochem Ireland are exclusively involved in API manufacturing, without any involvement in the finished dosage business.
This, together with complete financial independence of the group, puts the customer at ease for the lack of any potential conflict of interests.



AMSA, Cosma and Clarochem Ireland possess a wide array of facilities and technologies, supporting their activity of multipurpose factories.
Today the total reaction capability of the group is 250 cubic meters, comprising stainless steel and glass-lined vessels ranging all sizes from kilo-lab to 8000 l reactors, all in GMP.
In-house milling, micronisation and compaction equipment is available in our finishing areas (class 100.000) to satisfy most customer needs on powder properties.

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