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AMSA An. Mat. Sint. Affini S.p.A. Unipersonale
Registered Office: Viale del Ghisallo 20, 20151 Milano (MI) – Italy
R.E.A. Milano 601857
Cosma S.p.A. Unipersonale
Registered Office: Via Colleoni 15-17, 24040 Ciserano (BG) – Italy
R.E.A. Bergamo 167479
Clarochem Ireland Ltd.
Registered Office: Damastown, Mulhuddart, Dublin 15 – Republic of Ireland
VAT No. IE6517797I

COMSA_S©Albo-7 CFM Group With its three cGMP manufacturing companies, CFM Group is a well recognized global player in the active pharmaceutical ingredients industry, operating since 1949 with the primary focus to supply its products in highly regulated markets. AMSA, Cosma and Clarochem Ireland offer a wide portfolio and tailored solutions to both generics, brand pharmaceuticals and animal health players AMSA_m©Albo-24 CFM Group With its three cGMP manufacturing companies, CFM Group is a well recognized global player in the active pharmaceutical ingredients industry, operating since 1949 with the primary focus to supply its products in highly regulated markets. Amsa, Cosma and Clarochem Ireland offer a wide portfolio and tailored solutions to both generics, brand pharmaceuticals and animal health players COMSA©Albo-4 CFM Group With its three cGMP manufacturing companies, CFM Group is a well recognized global player in the active pharmaceutical ingredients industry, operating since 1949 with the primary focus to supply its products in highly regulated markets. Amsa, Cosma and Clarochem Ireland offer a wide portfolio and tailored solutions to both generics, brand pharmaceuticals and animal health players

Tradition, innovation, reliability

An over 100 years legacy

Since 1908 start of pharmacy family business in Milano, four generations have been involved in helping people all over the world to improve their health, by supporting drugs development, manufacturing and distribution with high quality ingredients.

Thanks to the direct, attentive care by the Rebuzzini family towards the changing needs of the chemical pharmaceutical business, a constant flow of investments in equipments, technology and skills allowed a significant growth and global expansion.

Today AMSA, Cosma and Clarochem operate with the highest degree of care to meet product quality and system requirements in adherence to USFDA, EDQM and JPMDA expectations, to minimize environmental impact through conscious chemical approach and to grant safe and rewarding jobs to their employees.

Tradition, innovation, reliability

An over 100 years legacy

Since 1908 start of pharmacy family business in Milano, four generations have been involved in helping people all over the world to improve their health, by supporting drugs development, manufacturing and distribution with high quality ingredients.

Thanks to the direct, attentive care by the Rebuzzini family towards the changing needs of the chemical pharmaceutical business, a constant flow of investments in equipments, technology and skills allowed a significant growth and global expansion.

Today AMSA, Cosma and Clarochem operate with the highest degree of care to meet product quality and system requirements in adherence to USFDA, EDQM and JPMDA expectations, to minimize environmental impact through conscious chemical approach and to grant safe and rewarding jobs to their employees.

AMSAS.p.A.

Based nearby the worldwide recognized beauties of Como Lake since 1953, when it was founded by Giuseppe Rebuzzini, AMSA is the first manufacturing company of the CFM group, although it was substantially renovated over the years. AMSA first gained US FDA approval in 1998. The production plant has a 60,000L capacity mostly utilized for small-medium volume APIs, in both generics and fast growing custom synthesis sector.

Cosma S.p.A.

Located in the area of Bergamo, northern Italy, it was founded in 1977 and developed with the specific aim to introduce CFM group into the USA generic market. Firstly approved in 1984 by US FDA, Cosma still sells above 50% of its entire production for such purpose. In addition to supporting global generic and brand pharmaceutical companies, Cosma has also developed a considerable presence in the animal health business, where it acquired a strong reputation by serving all the most important global players. With 130,000L capacity and above 300 tons APIs annual output, it is the largest site within the CFM group.

Clarochem Ireland Ltd

Following the acquisition of a state of the art chemical facility in Damastown, near Dublin, Clarochem was founded in 2009 to add approximetely 60,000L capacity to the group. With substantial room to expand, and after 2017 first US FDA approval, it is the perfect site for contract manufacturing opportunities but it has been also important to allow GMP starting materials and intermediates back-integration strategy to the benefit of all the companies in the group.

CFM Group products

Our products are just the most tangible part of what we do. There is so much behind, and so much ahead. At AMSA, Cosma and Clarochem, we create the conditions to offer high quality APIs from a comprehensive synthetic and analytical development approach, beside a stringent selection and control of our valuable starting materials suppliers.

We file and update our DMFs, ASMF, CEPs and VMFs all over the world and we provide our customers all the necessary scientific and regulatory support to obtain approvals and market successfully their finished dosage formulations, granting the highest level of compliance for our entire production.

Custom Synthesis

CFM Group products

Our products are just the most tangible part of what we do. There is so much behind, and so much ahead. At AMSA, Cosma and Clarochem, we create the conditions to offer high quality APIs from a comprehensive synthetic and analytical development approach, beside a stringent selection and control of our valuable starting materials suppliers.

We file and update our DMFs, ASMF, CEPs and VMFs all over the world and we provide our customers all the necessary scientific and regulatory support to obtain approvals and market successfully their finished dosage formulations, granting the highest level of compliance for our entire production.

Generic APIs

Custom Synthesis

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